I know that this has been brought before ( did do a form search) but I have tried just about everything. I have had this problem for over a year on my desktop. What I have been told by CW is that I have a problem with my USB's . I have two cards and readers, I have tried every port on the desktop. Windows 10 sees the reader is plug in and that it says something like setting up the software and then says ready to use. I know that both sets of readers and cards are good because they work on my laptop. My work around has been to copy the file to a memory stick from my desktop to my laptop than to the card. I had my son look at the software for the newest updates and other settings. Any ideals?